Mercer scored six runs in the final two innings, but it wasn't enough in a 10-7 loss Friday to visiting Austin Peay.
Austin Peay turned to the long ball to grab an early 2-0 lead, picking up a pair of solo home runs in the top of the second.
The Bears answered in the home half, thanks to back-to-back hits to lead off the inning.
The Governors added two more solo home runs to take a 4-1 lead they expanded to 9-1, aided by some Mercer defensive mistakes.
The Bears got a leadoff eighth-inning homer by Ben Upton, and then a three-run shot later in the inning by Charlie Madden.
Austin Peay added one in the ninth, and Mercer scored two in the ninth.
Mercer (7-3) and Austin Peay (5-4) play again at 2 p.m. Saturday.
Softball team splits opening games
Mercer team split its two games on the first day of the Black & Orange Challenge on Friday, beating Iowa State 9-3 and losing 8-3 to Boston College at Sikes Field.
Despite grabbing an early 3-0 lead, keyed by freshman Lindsay Boynton's first collegiate hit -- a two-RBI single up the middle -- in the first inning, Mercer dropped the opener to Boston College.
The Eagles chipped away at the Bears' lead, scoring two runs in the top of the third inning before eventually scoring three in the sixth.
Mercer used the big hit to defeat Iowa State, as Shaila Warren, Emma Andrew and Lindsay Boynton all hit home runs.
The Bears turned a 1-0 deficit after one into a 2-1 lead on Warren's two-run inside-the-park home run in the second inning.
Jill McElderry earned her second win of the season with 6-1/3 innings, quieting an Iowa State offense that entered the Black & Orange Challenge hitting .315 and put up 11 runs on Fordham on Friday morning.
Mercer (5-13) plays Fordham at 12:15 p.m. on Saturday.