Pacelli outscored Mount de Sales 28-3 over the final 35 minutes for a 35-17 win Friday in Macon.
The Vikings outgained the Cavaliers 415-257 in the win, with 328 of their yards coming on the ground.
Ben Davis led Pacelli's attack with 175 rushing yards and two touchdowns.
Mount de Sales' quarterback Pinkney Gilchrist passed for 190 yards and two touchdowns with Jordan Edwards catching eight passes for 96 yards.
The Cavaliers lost four turnovers in the defeat.