Gunmen made off with cash from the X-Mart on Emery Highway late Tuesday night after the business was robbed twice last month.
About 11 p.m., two slender black males approached clerks outside smoking cigarettes and ordered them back into the building, according to a news release from the Bibb County Sheriffs Office.
One of the men had a gun as they demanded money from the register and then got away with the loot.
The gunman with a bandana over his face was wearing a black, zipped up jacket, black pants and a White Sox black baseball cap.
The other man, who had a dark shirt or bandana over his face, was dressed in a burgundy hoodie and gray sweat pants.
Both men stood between 5 feet 7 and 5 feet 10 and were wearing socks over their hands during the holdup.
The store on a lonely stretch of road has been robbed at least a dozen times in recent years.
Anyone with information is urged to all Macon Regional CrimeStoppers at 877-68-CRIME.